abstract：BACKGROUND:Human kallikrein gene 6 (KLK6) is a member of the human kallikrein gene family (Kallikreins, KLKs). Human kallikrein-related peptidase 6 (hK6) is a trypsin-like serine protease encoded by the KLK6, has been reported to be highly expressed in several cancers including gastric cancer. In this study, we investi...

journal_title：Diagnostic pathology

authors： Liu X,Xiong H,Li J,He Y,Yuan X

更新日期：2013-04-15 00:00:00

abstract：UNLABELLED:Perivascular epithelioid cell tumor (PEComa) is a rare but distinct mesenchymal neoplasm composed of histologically and immunohistochemically unique perivascular epithelioid cells. Due to its relative rarity, little is known about the histogenesis and prognostic factors of this tumor. We describe a case of u...

journal_title：Diagnostic pathology

authors： Fu X,Jiang JH,Gu X,Li Z

更新日期：2013-04-15 00:00:00

abstract：BACKGROUND:Extra-adrenal paraganglioma of the retroperitoneum with metastasis to the vertebra is very rare. To our knowledge this is the first report of this kind of disease in the literature. CASE PRESENTATION:Here, we present an oroginal case of paraganglioma of the retroperitoneum with metastasis to the abdominal v...

journal_title：Diagnostic pathology

authors： He J,Wang X,Zheng W,Zhao Y

更新日期：2013-03-28 00:00:00

abstract：BACKGROUND:Rhabdoid colorectal tumor (RCT) is a rare, highly aggressive neoplasm recurrent in elderly patients, commonly at the caecum. The molecular mechanisms underlying RCT pathogenesis remain poorly elucidated. The differential diagnosis is with the malignant rhabdoid tumors of infancy characterized by genetic inac...

journal_title：Diagnostic pathology

authors： Pancione M,Remo A,Sabatino L,Zanella C,Votino C,Fucci A,Di Blasi A,Lepore G,Daniele B,Fenizia F,Molinari E,Normanno N,Manfrin E,Vendraminelli R,Colantuoni V

更新日期：2013-02-20 00:00:00

abstract：BACKGROUND:The uterine endometrial polyp (EMP) has a potential risk of developing malignant tumors especially in postmenopausal women. These malignancies include endometrial intraepithelial carcinoma (EIC). PATIENTS AND METHODS:Eight patients with EIC in the EMP, who were postmenopausal with ages ranging from 49 to 76...

journal_title：Diagnostic pathology

authors： Yasuda M,Katoh T,Hori S,Suzuki K,Ohno K,Maruyama M,Matsui N,Miyazaki S,Ogane N,Kameda Y

更新日期：2013-02-15 00:00:00

abstract：BACKGROUND:This study is an analysis of the prevalence of polymorphous low grade adenocarcinoma (PLGA) in epidemiological surveys of salivary tumors published in the English language from 1992 to 2012. METHODS:These surveys included studies from different researchers, countries and continents. The 57 surveys for which...

journal_title：Diagnostic pathology

authors： de Araujo VC,Passador-Santos F,Turssi C,Soares AB,de Araujo NS

更新日期：2013-01-15 00:00:00

abstract：UNLABELLED:Metastatic renal cell carcinoma in the gallbladder is extremely rare, with reported frequencies of less than 0.6% in large autopsy reviews. Only 40 cases were reported in the literature. We report a first case of gallbladder polypoid tumor revealing metastatic clear cell renal cell carcinoma, which demonstra...

journal_title：Diagnostic pathology

authors： Ghaouti M,Znati K,Jahid A,Zouaidia F,Bernoussi Z,El Fakir Y,Mahassini N

更新日期：2013-01-10 00:00:00

abstract：UNLABELLED:The differential diagnosis between idiopathic nonspecific interstitial pneumonia(INSIP) and idiopathic pulmonary fibrosis(IPF)/usual interstitial pneumonia(UIP)is tough in both clinicians and pathologists. In this study, we analyzed the lesions of right lung removed from a 58-year-old patient by gross and mi...

journal_title：Diagnostic pathology

authors： Fang X,Luo B,Yi X,Zeng Y,Liu F,Li H,Gu P,Zhu X,Zhang S,Jiang G

更新日期：2012-12-03 00:00:00

abstract：OBJECTIVE:MicroRNA-100 (miR-100) has been demonstrated to be downregulated in bladder cancer tissues, and enforced expression of this miRNA may inhibit cell growth and colony formation of human bladder cancer 5637 cells in vitro. However, the clinical significance of miR-100 in human bladder cancer has not yet been elu...

journal_title：Diagnostic pathology

authors： Wang S,Xue S,Dai Y,Yang J,Chen Z,Fang X,Zhou W,Wu W,Li Q

更新日期：2012-11-22 00:00:00

abstract：UNLABELLED:Lung cancer is the leading cause of death among malignant diseases in humans worldwide. In the last decade development of new targeted drugs for the treatment of non-small cell lung cancer proved to be a promising approach to prolong the otherwise very poor prognosis of patients with advanced UICC stages. Ep...

journal_title：Diagnostic pathology

authors： Otto C,Csanadi A,Fisch P,Werner M,Kayser G

更新日期：2012-10-22 00:00:00

abstract：BACKGROUND:World Health Organization (WHO) criteria are commonly used to diagnose plasma cell myeloma (PCM); however, these criteria are complex and require several laboratory parameters. For differentiating reactive plasmacytosis from clonal plasma cell (PC) neoplasms such as PCM, it is important to accurately determi...

journal_title：Diagnostic pathology

authors： Nakayama S,Yokote T,Hirata Y,Iwaki K,Akioka T,Miyoshi T,Takayama A,Nishiwaki U,Masuda Y,Ikemoto T,Tanaka H,Nishimura Y,Tsuji M,Hanafusa T

更新日期：2012-09-28 00:00:00

abstract：OBJECTIVES:This study consisted of two parts. One part was to analyze the survival rates of adenoid cystic carcinoma (ACC) in Chinese and explain the difference between our data and the literature. The other was to analyze the relationship between the expression of CD117 and the histological grade and the prognosis. M...

journal_title：Diagnostic pathology

authors： Zhou Q,Chang H,Zhang H,Han Y,Liu H

更新日期：2012-09-10 00:00:00

abstract：:Perivascular epithelioid cell (PEC) tumors (PEComas) are a family of related mesenchymal tumors composed of PECs which co-express melanocytic and smooth muscle markers. Although their distinctive histologic, immunohistochemical, ultrastructural, and genetic features have been clearly demonstrated, their histogenesis a...

journal_title：Diagnostic pathology

authors： Fang CL,Lin YH,Chen WY

更新日期：2012-09-03 00:00:00

abstract：UNLABELLED:Giant cell angioblastoma (GCAB) is an extremely rare soft tissue tumor of early childhood and only five cases have been described to date. As such the clinical, pathological, and prognostic features are poorly defined. We prensent here a new case of GCAB in bone of a child aged 4-years old. The lesion was co...

journal_title：Diagnostic pathology

authors： Mao RJ,Jiang ZM,Zhang HZ,Zhu XZ,Zhang QL

更新日期：2012-08-29 00:00:00

abstract：BACKGROUND:To distinguish between malignant and benign lesions of the thyroid gland histological demonstration is often required since the fine-needle aspiration biopsy method applied pre-operatively has some limitations. In an attempt to improve diagnostic accuracy, markers using immunocytochemistry and immunohistoche...

journal_title：Diagnostic pathology

authors： de Matos LL,Del Giglio AB,Matsubayashi CO,de Lima Farah M,Del Giglio A,da Silva Pinhal MA

更新日期：2012-08-13 00:00:00

abstract：BACKGROUND:Malignant melanoma is the most lethal form of skin cancer with a variable clinical course even in patients with thin melanomas and localized disease. Despite increasing insights into melanoma biology, no prognostic biomarkers have yet been incorporated into clinical protocols. Reduced expression of the RNA b...

journal_title：Diagnostic pathology

authors： Nodin B,Fridberg M,Jonsson L,Bergman J,Uhlén M,Jirström K

更新日期：2012-07-17 00:00:00

abstract：BACKGROUND:Acute promyelocytic leukemia is a cytogenetically well defined entity. Nevertheless, some features observed at diagnosis are related to a worse outcome of the patients. METHODS:In a prospective study, we analyzed peripheral (PB) leukocyte count, immunophenotype, methylation status of CDKN2B, CDKN2A and TP73...

journal_title：Diagnostic pathology

authors： De Mello MR,Albuquerque DM,Pereira-Cunha FG,Albanez KB,Pagnano KB,Costa FF,Metze K,Lorand-Metze I

更新日期：2012-06-28 00:00:00

abstract：BACKGROUND:It is not clear if sentinel lymph node (SLN) mapping can improve outcomes in patients with colorectal cancers. The purpose of this study was to determine the prognostic values of ex vivo sentinel lymph node (SLN) mapping and immunohistochemical (IHC) detection of SLN micrometastasis in colorectal cancers. M...

journal_title：Diagnostic pathology

authors： Wang FL,Shen F,Wan DS,Lu ZH,Li LR,Chen G,Wu XJ,Ding PR,Kong LH,Pan ZZ

更新日期：2012-06-22 00:00:00

abstract：:Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by recurrent coma, ventricular tachycardias and the replacement of the myocardium with fatty and fibrous tissue. We described a 42-year-old female patient without clinical arrhythmias which was diagnosed as ARVC by magnetic resonance imaging (MRI)...

journal_title：Diagnostic pathology

authors： Wei J,Tang J,Xia L,Chen X,Wang DW

更新日期：2012-06-12 00:00:00

abstract：BACKGROUND:c-MET is an oncogene protein that plays important role in gastric carcinogenesis and has been introduced as a prognostic marker and potential therapeutic target. The aim of this study was to evaluate the frequency of c-MET overexpression and its relationship with clinicopathological variables in gastric canc...

journal_title：Diagnostic pathology

authors： Sotoudeh K,Hashemi F,Madjd Z,Sadeghipour A,Molanaei S,Kalantary E

更新日期：2012-05-28 00:00:00

abstract：:Primary involvement of skeletal muscle is a very rare event in ALK-1 positive anaplastic large cell lymphoma (ALCL). We describe a case of a 10-year old boy presenting with a three week history of pain and a palpable firm swelling at the dorsal aspect of the left thigh. Histological examination of the lesion revealed ...

journal_title：Diagnostic pathology

authors： Gaiser T,Geissinger E,Schattenberg T,Scharf HP,Dürken M,Dinter D,Rosenwald A,Marx A

更新日期：2012-04-12 00:00:00

abstract：BACKGROUND:Assessment of hemoglobin is one of the most reliable indicators for anemia, and is widely used to screen for anemia among pregnant women. The HemoCue® has been widely used for as a point-of-care device for hemoglobin estimation in health facilities. Previous studies showed contradictory results regarding the...

journal_title：Diagnostic pathology

authors： Adam I,Ahmed S,Mahmoud MH,Yassin MI

更新日期：2012-03-21 00:00:00

abstract：:Non-necrotizing epithelioid granulomas have been described in association with many primary tumors. In such cases, they are designated as sarcoid-like reaction. Although it is more seen in carcinomas than in sarcomas, it is very rarely reported in renal carcinoma. Here, we describe a rare association of prominent peri...

journal_title：Diagnostic pathology

authors： Ouellet S,Albadine R,Sabbagh R

更新日期：2012-03-18 00:00:00

abstract：UNLABELLED:Seven percent of renal cell carcinoma (RCC) cases are diagnosed as "unclassified" RCC by morphology. Genetic profiling of RCCs helps define renal tumor subtypes, especially in cases where morphologic diagnosis is inconclusive. This report describes a patient with synchronous clear cell RCC (ccRCC) and a tubu...

journal_title：Diagnostic pathology

authors： Quiroga-Garza G,Piña-Oviedo S,Cuevas-Ocampo K,Goldfarb R,Schwartz MR,Ayala AG,Monzon FA

更新日期：2012-02-27 00:00:00

abstract：:Concurrent hematologic malignancies are relatively rare. We encountered a case of concurrent acute myeloid leukemia (AML) and T lymphoblastic lymphoma. The bone marrow chromosome analysis showed the karyotype 46, XY, t(5;12)(q33;p13), which indicated presence of PDGFRB gene translocations. Therefore, this disease belo...

journal_title：Diagnostic pathology

authors： Chang H,Chuang WY,Sun CF,Barnard MR

更新日期：2012-02-22 00:00:00

abstract：UNLABELLED:CD5-positive marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) of the lung is very rare. An 82-year-old Japanese woman was found to have an abnormal lung shadow on chest X-ray photography, and was admitted to our hospital. Imaging modalities including X-ray photography, computed t...

journal_title：Diagnostic pathology

authors： Terada T

更新日期：2012-02-14 00:00:00

abstract：:Two studies recently reported around 10% of EGFR activating mutations in triple negative breast cancers from Asian patients. However, we did not find any EGFR activating mutation in a series of 229 breast tumor samples from European patients. Like in lung cancer, the EGFR mutation profiles seem to be related to the et...

journal_title：Diagnostic pathology

authors： Lamy PJ,Jacot W

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND/OBJECTIVE:Metastatic adenocarcinoma from an unknown primary site is a common clinical problem. Determining the cytokeratin (CK) 7/CK20 pattern of tumors is one of the most helpful procedures for this purpose since the CK7-/CK20+ pattern is typical of colorectal adenocarcinomas. CDX2, a critical nuclear trans...

journal_title：Diagnostic pathology

authors： Bayrak R,Haltas H,Yenidunya S

更新日期：2012-01-23 00:00:00

abstract：:Primary pleural angiosarcoma is a rare and clinically aggressive tumor. Patients usually present with chest pain, dyspnea, hemoptysis and/or cough. Radiologic studies reveal diffuse pleural thickening and pleural effusion with or without mass lesion. The clinical and radiological features both resemble those of mesoth...

journal_title：Diagnostic pathology

authors： Kao YC,Chow JM,Wang KM,Fang CL,Chu JS,Chen CL

更新日期：2011-12-30 00:00:00

abstract：BACKGROUND:Although synovial sarcoma is the 3rd most commonly occurring mesenchymal tumor in young adults, usually with a highly aggressive clinical course; remarkable differences can be seen regarding the clinical outcome. According to comparative genomic hybridization (CGH) data published in the literature, the simpl...

journal_title：Diagnostic pathology

authors： Balogh Z,Szemlaky Z,Szendroi M,Antal I,Pápai Z,Fónyad L,Papp G,Changchien YC,Sápi Z

更新日期：2011-11-03 00:00:00

abstract：BACKGROUND:ABCG2 is an ABC transporter. It has been demonstrated that endogenous ABCG2 expression in certain cancers is a possible reflection of the differentiated phenotype of the cell of origin and likely contributes to intrinsic drug resistance. But little is known about the contribution of ABCG2 to the drug resista...

journal_title：Diagnostic pathology

authors： Xiang L,Su P,Xia S,Liu Z,Wang Y,Gao P,Zhou G

更新日期：2011-09-27 00:00:00

abstract：:Endocervicosis in the urinary bladder is a rare benign condition. We present a case in a 37-year-old woman with classical clinical and pathological features of endocervicosis. The unusual observation of endocervical-like mucinous epithelium in continuity with the urothelium in addition to fully developed endocervicosi...

journal_title：Diagnostic pathology

authors： Cheah PL,Looi LM,Lee GE,Teoh KH,Mun KS,Nazarina AR

更新日期：2011-06-23 00:00:00

abstract：BACKGROUND:The development of inhibitors against factor 8 (F8) is the most serious complication of replacement therapy with F8 in children with severe hemophilia. It was suggested that mismatched F8 replacement therapy may be a risk factor for the development of anti-factor F8 alloantibodies. Recently four single nucle...

journal_title：Diagnostic pathology

authors： Elmahmoudi H,Belhedi N,Jlizi A,Zahra K,Meddeb B,Ben Ammar Elgaaied A,Gouider E

更新日期：2011-06-17 00:00:00

abstract：BACKGROUND:Maspin is a unique member of the serine protease inhibitor superfamily and its expression is found in myoepithelial cells of normal mammary glands; therefore, it has been considered to be a myoepithelial marker. We previously reported that maspin was frequently expressed in biologically aggressive breast can...

journal_title：Diagnostic pathology

authors： Umekita Y,Ohi Y,Souda M,Rai Y,Sagara Y,Sagara Y,Tamada S,Tanimoto A

更新日期：2011-04-16 00:00:00

abstract：:Telepathology, the practice of pathology at a long distance, has advanced continuously since 1986. Today, fourth-generation telepathology systems, so-called virtual slide telepathology systems, are being used for education applications. Both conventional and innovative surgical pathology diagnostic services are being ...

journal_title：Diagnostic pathology

authors： Ayad E

更新日期：2011-03-30 00:00:00

abstract：:This study is an initial investigation on the capability of multispectral imaging to capture subtle spectral information that would enable the automatic delineation between the eosinophilic esophagitis and other eosin stained tissue components, especially the RBCs. In the method, a principal component analysis (PCA) w...

journal_title：Diagnostic pathology

authors： Bautista PA,Yagi Y

更新日期：2011-03-30 00:00:00

abstract：:Complement C4d component deposition in kidney allograft biopsies is an established marker of antibody-mediated rejection. In the Banff 07 classification of renal allograft pathology, semi-quantitative evaluation of the proportion of C4d-positive peritubular capilaries (PTC) is used. We aimed to explore the potential o...

journal_title：Diagnostic pathology

authors： Brazdziute E,Laurinavicius A

更新日期：2011-03-30 00:00:00

abstract：BACKGROUND:In recent years, a battery-powered bone marrow biopsy system was developed and cleared by the U.S. Food and Drug Administration to allow health care providers to access the bone marrow space quickly and efficiently. A multicenter randomized clinical trial was designed for adult patients to determine if the p...

journal_title：Diagnostic pathology

authors： Berenson JR,Yellin O,Blumenstein B,Bojanower D,Croopnick J,Aboulafia D,Upadhyaya G,Spadaccini C

更新日期：2011-03-23 00:00:00

abstract：:Diagnostic surgical pathology or tissue–based diagnosis still remains the most reliable and specific diagnostic medical procedure. The development of whole slide scanners permits the creation of virtual slides and to work on so-called virtual microscopes. In addition to interactive work on virtual slides approaches ha...

journal_title：Diagnostic pathology

authors： Kayser K,Görtler J,Borkenfeld S,Kayser G

更新日期：2011-01-01 00:00:00

abstract：:Giant cell tumor (GCT) of bone is a locally destructive tumor that occurs predominantly in long bones of post-pubertal adolescents and young adults, where it occurs in the epiphysis. The majority are treated by aggressive curettage or resection. Vascular invasion outside the boundary of the tumor can be seen. Metastas...

journal_title：Diagnostic pathology

authors： Miller IJ,Blank A,Yin SM,McNickle A,Gray R,Gitelis S

更新日期：2010-09-22 00:00:00